clinical depression

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : major depression, major depressive disorder

Mild depression is a normal condition, a sadness brought on by life's circumstances. Clinical depression, on the other hand, is a sadness so deep that it can lead to suicide if left untreated.

—Brenda Lane Richardson

Examples of clinical depression in a Sentence

Recent Examples on the Web

The Bell Jar Tracing the tangle of a new job in New York City and the simultaneous onrush of clinical depression, The Bell Jar brings the interior world of central character Esther Greenwood into stunning relief. — Caroline Rogers, Southern Living, 22 Aug. 2026

In 1972, vice-presidential candidate Thomas Eagleton withdrew from the Democratic ticket with George McGovern following disclosures that Eagleton had received electroshock therapy to treat clinical depression. — ABC News, 20 July 2026

In our conversation, Bonanno was careful to distinguish grief from clinical depression. — Amanda Petrusich, New Yorker, 22 June 2026

The most talented generation in decades is here to help an entire nation invent brand new, scientifically advanced ways to experience deep clinical depression. — Dieter Kurtenbach, Mercury News, 11 June 2026

Word History

First Known Use

1937, in the meaning defined above

Rhymes for clinical depression

• immunosuppression
• myelosuppression
• accession
• aggression
• compression
• concession
• confession
• digression
• discretion
• expression
• impression
• obsession

Medical Definition

clinical depression

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : major depression, major depressive disorder

Cases of clinical depression present doctors with a nasty diagnostic challenge: The malady, which strikes about 10% of the population, comes in myriad forms, each requiring different treatments.

—Science